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Light Chain Diversity among the Botulinum Neurotoxins

2 Jul 2018

Abstract excerpt

Botulinum neurotoxins (BoNT) are produced by several species of clostridium. There are seven immunologically unique BoNT serotypes (A–G). The Centers for Disease Control classifies BoNTs as ‘Category A’ select agents and are the most lethal protein toxins for humans. Recently, BoNT-like proteins have also been identified in several non-clostridia. BoNTs are di-chain proteins comprised of an N-terminal zinc...

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PMID: 30004421
DOI: 10.3390/toxins10070268

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