Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.

doi:10.1016/j.atherosclerosis.2017.09.031

Article

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.

Atherosclerosis - 1 Nov 2017

Strawbridge Rona J, Silveira Angela, Hoed Marcel den, Gustafsson Stefan, Luan Jian'an, Rybin Denis, Dupuis Josée, Li-Gao Ruifang, Kavousi Maryam, Dehghan Abbas, Haljas Kadri, Lahti Jari, Gådin Jesper R, Bäcklund Alexandra, de Faire Ulf, Gertow Karl, Giral Phillipe, Goel Anuj, Humphries Steve E, Kurl Sudhir, Langenberg Claudia, Lannfelt Lars L, Lind Lars, Lindgren Cecilia C M, Mannarino Elmo, Mook-Kanamori Dennis O, Morris Andrew P, de Mutsert Renée, Rauramaa Rainer, Saliba-Gustafsson Peter, Sennblad Bengt, Smit Andries J, Syvänen Ann-Christine, Tremoli Elena, Veglia Fabrizio, Zethelius Björn, Björck Hanna M, Eriksson Johan G, Hofman Albert, Franco Oscar H, Watkins Hugh, Jukema J Wouter, Florez Jose C, Wareham Nicholas J, Meigs James B, Ingelsson Erik, Baldassarre Damiano, Hamsten Anders

Abstract excerpt

BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated...

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Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.

Abstract excerpt

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