A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness).

doi:10.1007/s00125-014-3215-y

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Article

A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness).

Diabetologia - 1 Jun 2014

Strawbridge Rona J, Deleskog Anna, McLeod Olga, Folkersen Lasse, Kavousi Maryam, Gertow Karl, Baldassarre Damiano, Veglia Fabrizio, Leander Karin, Gigante Bruna, Kauhanen Jussi, Rauramaa Rainer, Smit Andries J, Mannarino Elmo, Giral Philippe, Dehghan Abbas, Hofman Albert, Franco Oscar H, Humphries Steve E, Tremoli Elena, de Faire Ulf, Gustafsson Sven, Östensson Claes-Göran, Eriksson Per, Öhrvik John, Hamsten Anders

Abstract excerpt

AIMS/HYPOTHESIS: The findings of studies investigating whether or not low serum 25-hydroxyvitamin D [25(OH)D] concentration promotes development of atherosclerosis have been contradictory. The present study employed a Mendelian randomisation approach and carotid artery intima-media thickness (cIMT), a surrogate marker of coronary artery disease, to address this question. METHODS: The multicentre, longitudinal...

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PMID: 24663808
DOI: 10.1007/s00125-014-3215-y

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DHCR7

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