Article

Bazedoxifene rescues sexually dimorphic autistic-like abnormalities in mice carrying a biallelic <i>MDGA1</i> mutation

2025-06-03

Abstract excerpt

In the accompanying study, we describe two pairs of MDGA1 missense mutations (Val116Met/Ala688Val and Tyr635Cys/Glu756Gln) from two patients with autism spectrum disorders (ASDs) and how these mutations exert distinct abnormalities in biological processes during central nervous system development. Here, we generated knockin (KI) mice harboring the murine version of Tyr635Cys/Glu756Gln MDGA1 ( Mdga1 Y636C/E751Q )...

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Literature Corpus work: 25685dc1-f689-57b4-bde5-a31ed7a905c4
DOI: 10.1101/2025.06.01.657278

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