Article
Association study of common genetic variants in pre-microRNAs in patients with ulcerative colitis.
Journal of clinical immunology - 1 Feb 2011
Okubo Masaaki, Tahara Tomomitsu, Shibata Tomoyuki, Yamashita Hiromi, Nakamura Masakatsu, Yoshioka Daisuke, Yonemura Joh, Kamiya Yoshio, Ishizuka Takamitsu, Nakagawa Yoshihito, Nagasaka Mitsuo, Iwata Masami, Yamada Hideto, Hirata Ichiro, Arisawa Tomiyasu
Abstract excerpt
BACKGROUND: Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population. METHODS: The rs11614913 (T > C), rs2910164 (C > G), and...