Article
A single-cell CRISPRi platform for characterizing candidate genes relevant to metabolic disorders in human adipocytes
24 Jul 2023
Abstract excerpt
Genomics efforts led to the identification of many genomic loci that are associated with metabolic traits, many of which are tied to adipose tissue function. However, determination of the causal genes, and their mechanism of action in metabolism, is a time-consuming process. Here, we use an approach to determine the transcriptional outcome of candidate gene knockdown for multiple genes at the same time in a human...
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