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Article

Discovering metabolic disease gene interactions by correlated effects on cellular morphology

13 Mar 2019

Abstract excerpt

OBJECTIVE: Impaired expansion of peripheral fat contributes to the pathogenesis of insulin resistance and Type 2 Diabetes (T2D). We aimed to identify novel disease-gene interactions during adipocyte differentiation. METHODS: Genes in disease-associated loci for T2D, adiposity and insulin resistance were ranked according to expression in human adipocytes. The top 125 genes were ablated in human pre-adipocytes via...

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PMID: 30940487
DOI: 10.1016/j.molmet.2019.03.001

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