Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue.

Molecular metabolism - 1 Oct 2017

Palmer Colin J, Bruckner Raphael J, Paulo Joao A, Kazak Lawrence, Long Jonathan Z, Mina Amir I, Deng Zhaoming, LeClair Katherine B, Hall Jessica A, Hong Shangyu, Zushin Peter-James H, Smith Kyle L, Gygi Steven P, Hagen Susan, Cohen David E, Banks Alexander S

Abstract excerpt

OBJECTIVES: Understanding how loci identified by genome wide association studies (GWAS) contribute to pathogenesis requires new mechanistic insights. Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused on the function of Cdkal1 as a tRNALys modifier and downstream effects of Cdkal1 loss on pro-insulin translational...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adipose Tissue, Brown

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adipose Tissue, White

Share to Adiposity

Share to Insulin-Secreting Cells

Share to Mice, Obese

Share to Mitochondrial Proteins

Share to tRNA Methyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 29031721
DOI: 10.1016/j.molmet.2017.07.013
PMCID: PMC5641635

Genes

CDKAL1
UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue.PMID 29031721Read ↗

Cdkn2a deficiency promotes adipose tissue browningSemantic proximity Read ↗

Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.Semantic proximity Read ↗

Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesisSemantic proximity Read ↗

Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes.Semantic proximity Read ↗

Mitochondrial Import of Malat1 Regulates Cardiac Mitochondrial Function in Type 2 Diabetes Mellitus through Interaction with MicroRNA-23bSemantic proximity Read ↗

Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis.Semantic proximity Read ↗

Uncoupling protein 1-driven Cre ( <i>Ucp1-Cre</i> ) is expressed in the epithelial cells of mammary glands and various non-adipose tissuesSemantic proximity Read ↗

Knock-Out of DHTKD1 Alters Mitochondrial Respiration and Function, and May Represent a Novel Pathway in Cardiometabolic Disease Risk.Semantic proximity Read ↗

CPEB2-activated Prdm16 translation promotes brown adipocyte function and prevents obesitySemantic proximity Read ↗

Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.Semantic proximity Read ↗

Adult-onset obesity is triggered by impaired mitochondrial gene expression.Semantic proximity Read ↗

Gene Regulation and Mitochondrial Activity During White and Brown Adipogenesis Are Modulated by KDM5 Histone DemethylaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.