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Article

Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes.

Endocrine journal - 1 Jan 2011

Wei Fan-Yan, Tomizawa Kazuhito

Abstract excerpt

A number of whole-genome association studies show the cdk5 regulatory associated protein 1-like 1 (cdkal1) gene to be one of the most reproducible risk genes in type 2 diabetes (T2D). Variations in the gene are associated with impaired insulin secretion but not insulin resistance or obesity. Although the physiological functions of Cdkal1 had been unclear, recent studies show that it is a tRNA modification...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21908934
DOI: 10.1507/endocrj.ej11-0099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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