Article
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Science advances - 1 Aug 2017
Perks Kara L, Ferreira Nicola, Richman Tara R, Ermer Judith A, Kuznetsova Irina, Shearwood Anne-Marie J, Lee Richard G, Viola Helena M, Johnstone Victoria P A, Matthews Vance, Hool Livia C, Rackham Oliver, Filipovska Aleksandra
Abstract excerpt
Mitochondrial gene expression is essential for energy production; however, an understanding of how it can influence physiology and metabolism is lacking. Several proteins from the pentatricopeptide repeat (PPR) family are essential for the regulation of mitochondrial gene expression, but the functions of the remaining members of this family are poorly understood. We created knockout mice to investigate the role...
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