Aubergine and piRNAs promote germline stem cell self‐renewal by repressing the proto‐oncogene Cbl

Abstract excerpt

Abstract PIWI proteins play essential roles in germ cells and stem cell lineages. In Drosophila , Piwi is required in somatic niche cells and germline stem cells (GSCs) to support GSC self‐renewal and differentiation. Whether and how other PIWI proteins are involved in GSC biology remains unknown. Here, we show that Aubergine (Aub), another PIWI protein, is intrinsically required in GSCs for their self‐renewal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer Mechanisms and Therapy
• Share to Chromosomal and Genetic Variations
• Share to CRISPR and Genetic Engineering