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Article

Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling.

Current biology : CB - 5 Aug 2013

Jin Zhigang, Flynt Alex S, Lai Eric C

Abstract excerpt

Drosophila Piwi is the founding member of a gonadal clade of Argonaute proteins that serve as silencing effectors for ∼26-32 nt Piwi-interacting RNAs (piRNAs) [1], and piwi mutants exhibit dramatically rudimentary ovaries [2]. It was proposed that somatic Piwi maintains germline stem cells (GSCs) by promoting Dpp signaling, presumably via cap cells that form the somatic niche for GSCs [3-5]. However, we...

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Identifiers

PMID: 23891114
DOI: 10.1016/j.cub.2013.06.021
PMCID: PMC3740069

Genes

GSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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