Article
Coordinated maternal imprinting and paternal genotype determined the ultimate level of hepatic cytochrome P-450 and associated monooxygenase activities.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Simpson V J, Zhau H E, Runner M N, Chung L W
Abstract excerpt
To understand the pre- and postnatal maternal influence on hepatic drug metabolism later in adult life, we have chosen to study the mouse hybrid (129/sv x LS) offspring derived from contrasting parental lines in a designated maternal environment. Results of these studies revealed that the following: 1) sex of the offspring was the major determinant for cytochrome P-450-specific content and for the activity of...
Topics
- Animals
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 Enzyme System
- Female
- Genotype
- Mice
- Mice, Inbred BALB C
- Microsomes, Liver
- NADPH-Ferrihemoprotein Reductase
- Pregnancy