Article
Dependence of acetazolamide teratogenesis on fetal and not maternal genotypes.
Reproductive toxicology (Elmsford, N.Y.) - 1 Jan 1992
Beck S L, Manabat N
Abstract excerpt
This study assesses the relative contributions of dam and conceptus to sensitivity to acetazolamide teratogenesis in an in vivo mouse model. Reciprocal F1 outcrosses were made between mice resistant to the teratogenic effects of acetazolamide (SWV) and the susceptible C57BL/6JBk line. Female F1 progeny were backcrossed either to C57BL or to SWV males. The F1 outcross resulted in identical fetuses developing in...
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