Genetic polymorphism of cytochrome P-450-dependent phencyclidine hydroxylation in mice. Comparison of phencyclidine hydroxylation in humans.

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Article

Genetic polymorphism of cytochrome P-450-dependent phencyclidine hydroxylation in mice. Comparison of phencyclidine hydroxylation in humans.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Holsztynska E J, Weber W W, Domino E F

Abstract excerpt

A mouse model of P-450 phencyclidine 3-cyclohydroxylase (P-450 PCP 3-cyclohydroxylase) genetic polymorphism is described. Up to a 3-fold difference was observed in the constitutive liver microsomal activity of P-450 PCP 3-cyclohydroxylase between "slow" (A/J and DBA/2J) and "rapid" (C57BL/6J and BALB/CJ) phencyclidine (PCP) metabolizers. The segregation of slow and rapid hydroxylator phenotypes between 17...

Topics

Animals
Cytochrome P-450 Enzyme System
Debrisoquin
Female
Humans
Hydroxylation
In Vitro Techniques
Male
Mice
Mice, Inbred A
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Inbred DBA

Mice, Inbred ICR

Microsomes, Liver

Phencyclidine

Phenotype

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 1673421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1673421-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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