Article
Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses.
Autism research : official journal of the International Society for Autism Research - 1 Feb 2011
Spencer Corinne M, Alekseyenko Olga, Hamilton Shannon M, Thomas Alexia M, Serysheva Ekaterina, Yuva-Paylor Lisa A, Paylor Richard
Abstract excerpt
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability in humans. In addition to cognitive impairment, patients may exhibit hyperactivity, attention deficits, social difficulties and anxiety, and autistic-like behaviors. The degree to which patients display these behaviors varies considerably and is influenced by family history, suggesting that genetic modifiers play a role in the...
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