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Article

The effect of background strain on the behavioral phenotypes of the MDGA2+/- mouse model of autism spectrum disorder.

Genes, brain, and behavior - 1 Mar 2021

Fertan Emre, Wong Aimée A, Purdon Michaela K, Weaver Ian C G, Brown Richard E

Abstract excerpt

The membrane-associated mucin (MAM) domain containing glycosylphosphatidylinositol anchor 2 protein single knock-out mice (MDGA2+/- ) are models of ASD. We examined the behavioral phenotypes of male and female MDGA2+/- and wildtype mice on C57BL6/NJ and C57BL6/N backgrounds at 2 months of age and measured MDGA2, neuroligin 1 and neuroligin 2 levels at 7 months. Mice on the C57BL6/NJ background performed better...

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PMID: 32808443
DOI: 10.1111/gbb.12696

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