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Article

Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease.

Mechanisms of ageing and development - 1 Nov 2006

Zschocke Johannes, Nebel Almut, Wicks Kate, Peters Verena, El Mokhtari Nour Eddine, Krawczak Michael, van der Woude Fokko, Janssen Bart, Schreiber Stefan

Abstract excerpt

Carnosine, a cytoprotective dipeptide found at very high concentrations in skeletal muscle, heart and brain, is cleaved in blood by serum carnosinase which is encoded by the CNDP1 gene. We recently found that homozygosity of a 5-leucine variant in the leader peptide of this enzyme protects diabetes mellitus patients against nephropathy. Hypothesising that the same allele could also be associated with longevity or...

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Identifiers

PMID: 16965804
DOI: 10.1016/j.mad.2006.08.002

Genes

CNDP1

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Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease.PMID 16965804Read ↗

Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.Semantic proximity Read ↗

A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans.Semantic proximity Read ↗

Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.Semantic proximity Read ↗

CNDP1 and Diabetic Kidney Disease: From Genetic Susceptibility to Therapeutic Targeting.Semantic proximity Read ↗

Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.Semantic proximity Read ↗

Association of CTG repeat polymorphism in carnosine dipeptidase 1 (CNDP1) gene with diabetic nephropathy in north Indians.Semantic proximity Read ↗

A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells.Semantic proximity Read ↗

Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.Semantic proximity Read ↗

D18S880 microsatellite polymorphism of carnosinase gene and diabetic nephropathy: a meta-analysis.Semantic proximity Read ↗

Association between CNDP1 genotype and diabetic nephropathy is sex specific.Semantic proximity Read ↗

CNDP1 (CTG)5 allele and cardiovascular events in high-risk patients: LURIC study results.Semantic proximity Read ↗

A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.Semantic proximity Read ↗

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