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Article

Ascribing a novel role for tmRNA of Escherichia coli in resistance to mitomycin C.

Future microbiology - 1 Nov 2017

Shanmughapriya Vinod, Richard Stephen, Nagarajan Tamilmaran, Munavar M Hussain

Abstract excerpt

AIM: The ssrA mutants were found to be more sensitive to mitomycin C (MMC) and our aim was to study this phenomenon in detail. MATERIALS & METHODS: Strains were constructed by P1 transduction. pssrA+ plasmid was constructed by PCR-based cloning and transformation was done by CaCl2 method. Relative viability analyses were done to assess the extent of viability of strains in relevant conditions. Gram staining was...

Topics

Alkylating Agents
Cell Division
Drug Resistance, Bacterial
Escherichia coli
Genetic Vectors
Microbial Viability
Mitomycin
Mutation
RNA, Bacterial
Transduction, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29027471
DOI: 10.2217/fmb-2016-0148

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