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Article

Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance.

Antimicrobial agents and chemotherapy - 1 Jan 2009

Ochi Kozo, Kim Ji-Yun, Tanaka Yukinori, Wang Guojun, Masuda Kenta, Nanamiya Hideaki, Okamoto Susumu, Tokuyama Shinji, Adachi Yoshikazu, Kawamura Fujio

Abstract excerpt

The methyltransferases RsmG and KsgA methylate the nucleotides G535 (RsmG) and A1518 and A1519 (KsgA) in 16S rRNA, and inactivation of the proteins by introducing mutations results in acquisition of low-level resistance to streptomycin and kasugamycin, respectively. In a Bacillus subtilis strain harboring a single rrn operon (rrnO), we found that spontaneous ksgA mutations conferring a modest level of resistance...

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Identifiers

PMID: 19001112
DOI: 10.1128/AAC.00873-08
PMCID: PMC2612157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance.PMID 19001112Read ↗

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