Article
Increased sensitivity to protein synthesis inhibitors in cells lacking tmRNA.
RNA (New York, N.Y.) - 1 Dec 2001
de la Cruz J, Vioque A
Abstract excerpt
tmRNA (also known as SsrA or 10Sa RNA) is involved in a trans-translation reaction that contributes to the recycling of stalled ribosomes at the 3' end of an mRNA lacking a stop codon or at an internal mRNA cluster of rare codons. Inactivation of the ssrA gene in most bacteria results in viable cells bearing subtle phenotypes, such as temperature-sensitive growth. Herein, we report on the functional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.