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Article

Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice

31 Oct 2007

Abstract excerpt

The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE(-/-)) mice fed a high-fat diet. This is associated with reduced plasma sphingomyelin (SM) and glycosphingolipid levels. Furthermore, oral administration of myriocin decreases plasma cholesterol and triglyceride (TG) levels. Here, we aimed to determine whether...

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PMID: 17978313
DOI: 10.1194/jlr.m700261-jlr200

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