Article
Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.
Human molecular genetics - 1 Sept 2001
Altafaj X, Dierssen M, Baamonde C, Martí E, Visa J, Guimerà J, Oset M, González J R, Flórez J, Fillat C, Estivill X
Abstract excerpt
Down's syndrome (DS) is a major cause of mental retardation, hypotonia and delayed development. Murine models of DS carrying large murine or human genomic fragments show motor alterations and memory deficits. The specific genes responsible for these phenotypic alterations have not yet been defined. DYRK1A, the human homolog of the Drosophila minibrain gene, maps to the DS critical region of human chromosome 21...
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