Article

Loss of <i>DYRK1A</i> ortholog <i>mbk-1</i> impairs locomotor behavior in <i>Caenorhabditis elegans</i>

2025-11-05

Abstract excerpt

Dual-specificity tyrosine phosphorylation-regulated kinase 1A ( DYRK1A ) is a dosage sensitive gene located on human chromosome 21 (Hsa21) that contributes to phenotypes associated with developmental disorders like Down syndrome and DYRK1A haploinsufficiency syndrome. Complete genetic knockout of Dyrk1a from conception is embryonic lethal, presenting a barrier in its study. The mbk-1 gene in Caenorhabditis el...

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Literature Corpus work: 9ad1e77a-995d-5fd9-bf46-850cea40d360
DOI: 10.1101/2025.11.04.686526

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