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Article

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice.

Molecular and cellular biology - 1 Sept 2002

Fotaki Vassiliki, Dierssen Mara, Alcántara Soledad, Martínez Salvador, Martí Eulàlia, Casas Caty, Visa Joana, Soriano Eduardo, Estivill Xavier, Arbonés Maria L

Abstract excerpt

DYRK1A is the human orthologue of the Drosophila minibrain (mnb) gene, which is involved in postembryonic neurogenesis in flies. Because of its mapping position on chromosome 21 and the neurobehavioral alterations shown by mice overexpressing this gene, involvement of DYRK1A in some of the neurological defects of Down syndrome patients has been suggested. To gain insight into its physiological role, we have...

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Identifiers

PMID: 12192061
DOI: 10.1128/MCB.22.18.6636-6647.2002
PMCID: PMC135639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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