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Article

An eQTL variant of ZXDC is associated with IFN-γ production following Mycobacterium tuberculosis antigen-specific stimulation.

Scientific reports - 9 Oct 2017

Jabot-Hanin Fabienne, Cobat Aurélie, Feinberg Jacqueline, Orlova Marianna, Niay Jonathan, Deswarte Caroline, Poirier Christine, Theodorou Ioannis, Bustamante Jacinta, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent, Alcaïs Alexandre, Hoal Eileen G, Delacourt Christophe, Schurr Erwin, Abel Laurent

Abstract excerpt

There is a large inter-individual variability in the response to Mycobacterium tuberculosis infection. In previous linkage analyses, we identified a major locus on chromosome region 8q controlling IFN-γ production after stimulation with live BCG (Bacillus Calmette-Guérin), and a second locus on chromosome region 3q affecting IFN-γ production triggered by the 6-kDa early secretory antigen target (ESAT-6), taking...

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Share to Antigens, Bacterial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28993696
DOI: 10.1038/s41598-017-13017-8
PMCID: PMC5634485

Genes

ZXDC
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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