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Article

Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis.

PLoS genetics - 1 Jun 2011

Marquis Jean-François, Kapoustina Oxana, Langlais David, Ruddy Rebecca, Dufour Catherine Rosa, Kim Bae-Hoon, MacMicking John D, Giguère Vincent, Gros Philippe

Abstract excerpt

IRF8 (Interferon Regulatory Factor 8) plays an important role in defenses against intracellular pathogens, including several aspects of myeloid cells function. It is required for ontogeny and maturation of macrophages and dendritic cells, for activation of anti-microbial defenses, and for production of the Th1-polarizing cytokine interleukin-12 (IL-12) in response to interferon gamma (IFNγ) and protection against...

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Identifiers

PMID: 21731497
DOI: 10.1371/journal.pgen.1002097
PMCID: PMC3121741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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