Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations.

doi:10.1093/infdis/jiv757

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations.

The Journal of infectious diseases - 1 Apr 2016

Jabot-Hanin Fabienne, Cobat Aurélie, Feinberg Jacqueline, Grange Ghislain, Remus Natascha, Poirier Christine, Boland-Auge Anne, Besse Céline, Bustamante Jacinta, Boisson-Dupuis Stéphanie, Casanova Jean-Laurent, Schurr Erwin, Alcaïs Alexandre, Hoal Eileen G, Delacourt Christophe, Abel Laurent

Abstract excerpt

BACKGROUND: Interferon γ (IFN-γ) release assays (IGRAs) provide an in vitro measurement of antimycobacterial immunity that is widely used as a test for Mycobacterium tuberculosis infection. IGRA outcomes are highly heritable in various populations, but the nature of the involved genetic factors remains unknown. METHODS: We conducted a genome-wide linkage analysis of IGRA phenotypes in families from a tuberculosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 3

Share to Chromosomes, Human, Pair 8

Share to France

Share to Interferon-gamma

Share to Mycobacterium bovis

Share to South Africa

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 26690346
DOI: 10.1093/infdis/jiv757
PMCID: PMC4779307

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations.PMID 26690346Read ↗

An eQTL variant of ZXDC is associated with IFN-γ production following Mycobacterium tuberculosis antigen-specific stimulation.Semantic proximity Read ↗

Mycobacterium africanum elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and their household contacts.Semantic proximity Read ↗

High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease.Semantic proximity Read ↗

Endogenously activated interleukin-4 differentiates disease progressors and non-progressors in tuberculosis susceptible families: a 2-year biomarkers follow-up study.Semantic proximity Read ↗

Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis.Semantic proximity Read ↗

Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis.Semantic proximity Read ↗

Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations.Semantic proximity Read ↗

Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.Semantic proximity Read ↗

Phenotypic and immune functional profiling of patients with suspected Mendelian Susceptibility to Mycobacterial Disease in South Africa.Semantic proximity Read ↗

IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians.Semantic proximity Read ↗

Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco.Semantic proximity Read ↗

Cytokine gene polymorphisms are associated with susceptibility to tuberculosis in an Amerindian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.