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Prevalence and spectrum of germline rare variants in BRCA1/2 and PALB2 among breast cancer cases in Sarawak, Malaysia.

Breast cancer research and treatment - 1 Oct 2017

Yang Xiaohong R, Devi Beena C R, Sung Hyuna, Guida Jennifer, Mucaki Eliseos J, Xiao Yanzi, Best Ana, Garland Lisa, Xie Yi, Hu Nan, Rodriguez-Herrera Maria, Wang Chaoyu, Jones Kristine, Luo Wen, Hicks Belynda, Tang Tieng Swee, Moitra Karobi, Rogan Peter K, Dean Michael

Abstract excerpt

PURPOSE: To characterize the spectrum of germline mutations in BRCA1, BRCA2, and PALB2 in population-based unselected breast cancer cases in an Asian population. METHODS: Germline DNA from 467 breast cancer patients in Sarawak General Hospital, Malaysia, where 93% of the breast cancer patients in Sarawak are treated, was sequenced for the entire coding region of BRCA1; BRCA2; PALB2; Exons 6, 7, and 8 of TP53; and...

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Identifiers

PMID: 28664506
DOI: 10.1007/s10549-017-4356-8
PMCID: PMC7032652

Genes

BRCA1
BRCA2
PALB2
PTEN

Provenance

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