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Identification of germline alterations in breast cancer predisposition genes among Malaysian breast cancer patients using panel testing.

Clinical genetics - 1 Oct 2016

Ng P S, Wen W X, Fadlullah M Z H, Yoon S Y, Lee S Y, Thong M K, Yip C H, Mohd Taib N A, Teo S H

Abstract excerpt

Although an association between protein-truncating variants and breast cancer risk has been established for 11 genes, only alterations in BRCA1, BRCA2, TP53 and PALB2 have been reported in Asian populations. Given that the age of onset of breast cancer is lower in Asians, it is estimated that inherited predisposition to breast cancer may be more significant. To determine the potential utility of panel testing, we...

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Source

Identifiers

PMID: 26757417
DOI: 10.1111/cge.12735

Genes

BRCA2
BRCA1
BARD1
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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