Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Graf regulates hematopoiesis through GEEC endocytosis of EGFR.

Development (Cambridge, England) - 15 Nov 2017

Kim Sungdae, Nahm Minyeop, Kim Najin, Kwon Yumi, Kim Joohyung, Choi Sukwoo, Choi Eun Young, Shim Jiwon, Lee Cheolju, Lee Seungbok

Abstract excerpt

GTPase regulator associated with focal adhesion kinase 1 (GRAF1) is an essential component of the GPI-enriched endocytic compartment (GEEC) endocytosis pathway. Mutations in the human GRAF1 gene are associated with acute myeloid leukemia, but its normal role in myeloid cell development remains unclear. We show that Graf, the Drosophila ortholog of GRAF1, is expressed and specifically localizes to GEEC endocytic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Compartmentation
Share to Clathrin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Glycosylphosphatidylinositols

Share to Hematopoiesis

Share to Hemocytes

Share to Proto-Oncogene Proteins c-cbl

Share to Ubiquitination

Source

Identifiers

PMID: 28993397
DOI: 10.1242/dev.153288

Genes

EGFR
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Graf regulates hematopoiesis through GEEC endocytosis of EGFR.PMID 28993397Read ↗

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.Semantic proximity Read ↗

Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia.Semantic proximity Read ↗

MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cellsSemantic proximity Read ↗

Loss of the BCR-FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B-Lymphomagenesis in MiceSemantic proximity Read ↗

Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf.Semantic proximity Read ↗

Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function.Semantic proximity Read ↗

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.Semantic proximity Read ↗

MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cellsSemantic proximity Read ↗

The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation.Semantic proximity Read ↗

Dynein and Star interact in EGFR signaling and ligand trafficking.Semantic proximity Read ↗

Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1.Semantic proximity Read ↗

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.