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Article

Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf.

Blood - 11 Nov 2010

Isern Joan, Fraser Stuart T, He Zhiyong, Zhang Hailan, Baron Margaret H

Abstract excerpt

The primitive erythroid (EryP) lineage is the first to differentiate during mammalian embryogenesis. Eklf/Klf1 is a transcriptional regulator that is essential for definitive erythropoiesis in the fetal liver. Dissection of the role(s) of Eklf within the EryP compartment has been confounded by th...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20720183
DOI: 10.1182/blood-2010-04-281196
PMCID: PMC2981545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20720183-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf.PMID 20720183Read ↗

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A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell–derived primitive hematopoiesisSemantic proximity Read ↗

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Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.Semantic proximity Read ↗

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