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Article

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.

Nature communications - 28 Jun 2017

Laviolette Laura A, Mermoud Julien, Calvo Isabel A, Olson Nicholas, Boukhali Myriam, Steinlein Ortrud K, Roider Elisabeth, Sattler Elke C, Huang Dachuan, Teh Bin Tean, Motamedi Mo, Haas Wilhelm, Iliopoulos Othon

Abstract excerpt

Germline mutations in the Folliculin (FLCN) tumour suppressor gene result in fibrofolliculomas, lung cysts and renal cancers, but the precise mechanisms of tumour suppression by FLCN remain elusive. Here we identify Rab7A, a small GTPase important for endocytic trafficking, as a novel FLCN interacting protein and demonstrate that FLCN acts as a Rab7A GTPase-activating protein. FLCN-/- cells display slower...

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Source

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Identifiers

PMID: 28656962
DOI: 10.1038/ncomms15866
PMCID: PMC5493755

Genes

FLCN
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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