Article

Lcn2 deficiency leads to social impairments independent of maternal immune activation

2025-06-28

Abstract excerpt

Maternal infection during pregnancy is a well-established risk factor for neurodevelopmental disorders (NDDs), yet the underlying molecular mechanisms remain poorly understood. Lipocalin-2 (Lcn2), an innate immune protein that is highly upregulated during infection, also affects neuronal and glial function. This study investigates the role of Lcn2 in shaping brain development, particularly after maternal immune ac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84756c8f-065d-55f7-b5d4-53b3606e2e59
DOI: 10.1101/2025.06.27.661499

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lcn2 deficiency leads to social impairments independent of maternal immune activationDOI 10.1101/2025.06.27.661499Read

Maternal immune activation, central nervous system development and behavioral phenotypesSemantic proximity Read

Maternal immune activation: Implications for neuropsychiatric disordersSemantic proximity Read

Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring.Semantic proximity Read

Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in human and rodent studiesSemantic proximity Read

The role of maternal immune activation in immunological and neurological pathogenesis of autismSemantic proximity Read

A temporal map of maternal immune activation-induced changes reveals a shift in neurodevelopmental timing and perturbed cortical development in miceSemantic proximity Read

Immune imbalance of global gene expression, and cytokine, chemokine and selectin levels in the brains of offspring with social deficits via maternal immune activationSemantic proximity Read

At the crux of maternal immune activation: Viruses, microglia, microbes, and <scp>IL‐17A</scp>Semantic proximity Read

Maternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disordersSemantic proximity Read

The Role of Immune Factors in Shaping Fetal NeurodevelopmentSemantic proximity Read

Maternal Immune Activation Alters Temporal Precision of Spike Generation of CA1 Pyramidal Neurons by Unbalancing GABAergic Inhibition in the OffspringSemantic proximity Read

Embryonic and adult synaptic proteome perturbations after maternal immune activation: Identification of persistent changes relevant for early interventionSemantic proximity Read