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Article

MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge.

Scientific reports - 26 May 2021

Zalosnik M I, Fabio M C, Bertoldi M L, Castañares C N, Degano A L

Abstract excerpt

Rett syndrome is a severe and progressive neurological disorder linked to mutations in the MeCP2 gene. It has been suggested that immune alterations may play an active role in the generation and/or maintenance of RTT phenotypes. However, there is no clear consensus about which pathways are regulated in vivo by MeCP2 in the context of immune activation. In the present work we set to characterize the role of MeCP2...

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Share to Autoimmunity
Share to CX3C Chemokine Receptor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Forkhead Transcription Factors

Share to Methyl-CpG-Binding Protein 2

Share to Neuroinflammatory Diseases

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Source

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Identifiers

PMID: 34040112
DOI: 10.1038/s41598-021-90517-8
PMCID: PMC8155097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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