Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.

doi:10.1074/jbc.M116.720870

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Article

Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.

The Journal of biological chemistry - 2 Sept 2016

Yugami Masaki, Odagiri Haruki, Endo Motoyoshi, Tsutsuki Hiroyasu, Fujii Shigemoto, Kadomatsu Tsuyoshi, Masuda Tetsuro, Miyata Keishi, Terada Kazutoyo, Tanoue Hironori, Ito Hitoshi, Morinaga Jun, Horiguchi Haruki, Sugizaki Taichi, Akaike Takaaki, Gotoh Tomomi, Takai Toshiyuki, Sawa Tomohiro, Mizuta Hiroshi, Oike Yuichi

Abstract excerpt

Macrophages play crucial roles in combatting infectious disease by promoting inflammation and phagocytosis. Angiopoietin-like protein 2 (ANGPTL2) is a secreted factor that induces tissue inflammation by attracting and activating macrophages to produce inflammatory cytokines in chronic inflammation-associated diseases such as obesity-associated metabolic syndrome, atherosclerosis, and rheumatoid arthritis. Here,...

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Identifiers

PMID: 27402837
DOI: 10.1074/jbc.M116.720870
PMCID: PMC5009257

Genes

ANGPTL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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