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Article

miR‑342‑5p promotes Zmpste24‑deficient mouse embryonic fibroblasts proliferation by suppressing GAS2.

Molecular medicine reports - 1 Dec 2017

Zhang Chun-Long, Liu Xinguang, He Qiu-Jing, Zheng Huiling, Xu Shun, Xiong Xing-Dong, Yuan Yuan, Ruan Jie, Li Jiang-Bin, Xing Yu, Zhou Zhongjun, Deng Shixiong

Abstract excerpt

Cellular senescence is an irreversible growth arrest of cells that maintain their metabolic activities. Premature senescence can be induced by different stress factors and occurs in mouse embryonic fibroblasts (MEFs) derived from Zmpste24 metalloproteinase‑deficient mice, a progeria mouse model of Hutchinson‑Gilford Progeria Syndrome. Previous studies have shown that miR‑342‑5p, an intronic microRNA (miRNA/miR)...

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Identifiers

PMID: 28990109
DOI: 10.3892/mmr.2017.7731
PMCID: PMC5779978

Genes

GAS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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