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Article

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

Nature communications - 1 Jan 2013

de la Rosa Jorge, Freije José M P, Cabanillas Rubén, Osorio Fernando G, Fraga Mario F, Fernández-García M Soledad, Rad Roland, Fanjul Víctor, Ugalde Alejandro P, Liang Qi, Prosser Haydn M, Bradley Allan, Cadiñanos Juan, López-Otín Carlos

Abstract excerpt

Defining the relationship between ageing and cancer is a crucial but challenging task. Mice deficient in Zmpste24, a metalloproteinase mutated in human progeria and involved in nuclear prelamin A maturation, recapitulate multiple features of ageing. However, their short lifespan and serious cell-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23917225
DOI: 10.1038/ncomms3268
PMCID: PMC3758871

Genes

ZMPSTE24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23917225-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.PMID 23917225Read ↗

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Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in miceSemantic proximity Read ↗

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