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Article

Endothelial and systemic upregulation of miR-34a-5p fine-tunes senescence in progeria

12 Jan 2022

Abstract excerpt

Endothelial defects significantly contribute to cardiovascular pathology in the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Using an endothelium-specific progeria mouse model, we identify a novel, endothelium-specific microRNA (miR) signature linked to the p53-senescence pathway and a senescence-associated secretory phenotype (SASP). Progerin-expressing endothelial cells exert profound...

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PMID: 35020601
DOI: 10.18632/aging.203820

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