Article
DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.
American journal of human genetics - 7 Dec 2017
Richard Melissa A, Huan Tianxiao, Ligthart Symen, Gondalia Rahul, Jhun Min A, Brody Jennifer A, Irvin Marguerite R, Marioni Riccardo, Shen Jincheng, Tsai Pei-Chien, Montasser May E, Jia Yucheng, Syme Catriona, Salfati Elias L, Boerwinkle Eric, Guan Weihua, Mosley Thomas H, Bressler Jan, Morrison Alanna C, Liu Chunyu, Mendelson Michael M, Uitterlinden André G, van Meurs Joyce B, Franco Oscar H, Zhang Guosheng, Li Yun, Stewart James D, Bis Joshua C, Psaty Bruce M, Chen Yii-Der Ida, Kardia Sharon L R, Zhao Wei, Turner Stephen T, Absher Devin, Aslibekyan Stella, Starr John M, McRae Allan F, Hou Lifang, Just Allan C, Schwartz Joel D, Vokonas Pantel S, Menni Cristina, Spector Tim D, Shuldiner Alan, Damcott Coleen M, Rotter Jerome I, Palmas Walter, Liu Yongmei, Paus Tomáš, Horvath Steve, O'Connell Jeffrey R, Guo Xiuqing, Pausova Zdenka, Assimes Themistocles L, Sotoodehnia Nona, Smith Jennifer A, Arnett Donna K, Deary Ian J, Baccarelli Andrea A, Bell Jordana T, Whitsel Eric, Dehghan Abbas, Levy Daniel, Fornage Myriam
Abstract excerpt
Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability. We therefore conducted a two-stage meta-analysis of the cross-sectional associations of systolic...
Read the complete abstract on PubMed