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Article

A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.

PLoS pathogens - 1 Jan 2013

Griffiths Samantha J, Koegl Manfred, Boutell Chris, Zenner Helen L, Crump Colin M, Pica Francesca, Gonzalez Orland, Friedel Caroline C, Barry Gerald, Martin Kim, Craigon Marie H, Chen Rui, Kaza Lakshmi N, Fossum Even, Fazakerley John K, Efstathiou Stacey, Volpi Antonio, Zimmer Ralf, Ghazal Peter, Haas Jürgen

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus causing vesicular oral or genital skin lesions, meningitis and other diseases particularly harmful in immunocompromised individuals. To comprehensively investigate the complex interaction between HSV-1 and its host we combined two genome-...

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Identifiers

PMID: 23950709
DOI: 10.1371/journal.ppat.1003514
PMCID: PMC3738494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23950709-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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