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Article

Independent and Correlated Role of Apolipoprotein E ɛ4 Genotype and Herpes Simplex Virus Type 1 in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Zhang Li-Na, Li Meng-Jie, Shang Ying-Hui, Zhao Fan-Fan, Huang Han-Chang, Lao Feng-Xue

Abstract excerpt

The ɛ4 allele of the Apolipoprotein E (APOE) gene in individuals infected by Herpes simplex virus type 1 (HSV-1) has been demonstrated to be a risk factor in Alzheimer's disease (AD). APOE-ɛ4 reduces the levels of neuronal cholesterol, interferes with the transportation of cholesterol, impairs repair of synapses, decreases the clearance of neurotoxic peptide amyloid-β (Aβ), and promotes the deposition of amyloid...

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Alzheimer Disease
Apolipoprotein E4
Brain
Genotype
Herpesvirus 1, Human

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PMID: 32804091
DOI: 10.3233/JAD-200607

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