Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades.

Neurochemistry international - 1 May 2008

Carter C J

Abstract excerpt

The products of the Herpes simplex (HSV-1) genome interact with many Alzheimer's disease susceptibility genes or proteins. These in turn affect those of the virus. For example, HSV-1 binds to heparan sulphate proteoglycans (HSPG2), or alpha-2-macroglobulin (A2M), and enters cells via nectin receptors, which are cleaved by gamma-secretase (APH1B, PSEN1, PSEN2, PEN2, NCSTN). The virus also binds to blood-borne...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Genome, Viral
Share to Herpes Simplex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Signal Transduction

Share to Simplexvirus

Share to Transcriptional Activation

Share to Viral Proteins

Share to Virus Integration

Source

Identifiers

PMID: 18164103
DOI: 10.1016/j.neuint.2007.11.003

Genes

APOE
APP
MAPT
PSEN2
DAPK1
DHCR24
FAS
FDPS
HMGCR
HSPG2
LMNA
NCSTN
PARP1
PSEN1
TAP2
TFCP2
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades.PMID 18164103Read ↗

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s DiseaseSemantic proximity Read ↗

Alzheimer's Disease: A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent MannerSemantic proximity Read ↗

APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle.Semantic proximity Read ↗

Gene signature in Alzheimer's disease and environmental factors: the virus chronicle.Semantic proximity Read ↗

Herpes simplex virus type 1 and Alzheimerâ€™s disease: increasing evidence for a major role of the virusSemantic proximity Read ↗

The association of herpes simplex virus and Alzheimer's disease: a potential synthesis of genetic and environmental factors.Semantic proximity Read ↗

Herpes simplex virus type 1, apolipoprotein E, and cholesterol: a dangerous liaison in Alzheimer's disease and other disorders.Semantic proximity Read ↗

APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells.Semantic proximity Read ↗

Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders.Semantic proximity Read ↗

Independent and Correlated Role of Apolipoprotein E ɛ4 Genotype and Herpes Simplex Virus Type 1 in Alzheimer's Disease.Semantic proximity Read ↗

Insights into the pathogenesis of herpes simplex encephalitis from mouse models.Semantic proximity Read ↗

From Viral Infections to Alzheimer’s Disease: Unveiling the Mechanistic Links Through Systems BioinformaticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.