Article
A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China.
The British journal of dermatology - 1 Apr 2018
Wang D, Zhang D-F, Li G-D, Bi R, Fan Y, Wu Y, Yu X-F, Long H, Li Y-Y, Yao Y-G
Abstract excerpt
BACKGROUND: Patients with leprosy have a very low risk of Alzheimer disease (AD) and β-amyloid (Aβ) deposition is significantly lower in the brain tissue of elderly patients with leprosy compared with age-matched controls. Apolipoprotein E (ApoE) plays a critical role in lipid metabolic pathways and in the brain, facilitating the proteolytic clearance of Aβ. We hypothesized that APOE confers risk of leprosy as...
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