Article
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
Nature genetics - 1 Mar 2015
Liu Hong, Irwanto Astrid, Fu Xi'an, Yu Gongqi, Yu Yongxiang, Sun Yonghu, Wang Chuan, Wang Zhenzhen, Okada Yukinori, Low Huiqi, Li Yi, Liany Herty, Chen Mingfei, Bao Fangfang, Li Jinghui, You Jiabao, Zhang Qilin, Liu Jian, Chu Tongsheng, Andiappan Anand Kumar, Wang Na, Niu Guiye, Liu Dianchang, Yu Xiulu, Zhang Lin, Tian Hongqing, Zhou Guizhi, Rotzschke Olaf, Chen Shumin, Zhang Xuejun, Liu Jianjun, Zhang Furen
Abstract excerpt
Genome-wide association studies (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, providing biological insight into the role of host genetic factors in mycobacterial infection. However, the identified loci only partially explain disease heritability, and additional genetic risk factors remain to be discovered. We performed a 3-stage GWAS of leprosy in the Chinese...
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