Article
Genetics of leprosy: expected and unexpected developments and perspectives.
Clinics in dermatology - 1 Jan 2000
Sauer Monica E D, Salomão Heloisa, Ramos Geovana B, D'Espindula Helena R S, Rodrigues Rafael S A, Macedo Wilian C, Sindeaux Renata H M, Mira Marcelo T
Abstract excerpt
A solid body of evidence produced over decades of intense research supports the hypothesis that leprosy phenotypes are largely dependent on the genetic characteristics of the host. The early evidence of a major gene effect controlling susceptibility to leprosy came from studies of familial aggregation, twins, and Complex Segregation Analysis. Later, linkage and association analysis, first applied to the...
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