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Article

Leprosy and the human genome.

Microbiology and molecular biology reviews : MMBR - 1 Dec 2010

Misch Elizabeth A, Berrington William R, Vary James C, Hawn Thomas R

Abstract excerpt

Despite the availability of effective treatment for several decades, leprosy remains an important medical problem in many regions of the world. Infection with Mycobacterium leprae can produce paucibacillary disease, characterized by well-formed granulomas and a Th1 T-cell response, or multibacillary disease, characterized by poorly organized cellular infiltrates and Th2 cytokines. These diametric immune responses...

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Identifiers

PMID: 21119019
DOI: 10.1128/MMBR.00025-10
PMCID: PMC3008172

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