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Article

The ribonuclease activity of Csm6 is required for anti-plasmid immunity by Type III-A CRISPR-Cas systems.

RNA biology - 1 Apr 2019

Foster Kawanda, Kalter Joshua, Woodside Walter, Terns Rebecca M, Terns Michael P

Abstract excerpt

CRISPR-Cas systems provide prokaryotes with RNA-based adaptive immunity against viruses and plasmids. A unique feature of Type III CRISPR-Cas systems is that they selectively target transcriptionally-active invader DNA, and can cleave both the expressed RNA transcripts and source DNA. The Type III-A effector crRNP (CRISPR RNA-Cas protein complex), which contains Cas proteins Csm1-5, recognizes and degrades...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29995577
DOI: 10.1080/15476286.2018.1493334
PMCID: PMC6546353

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