Article
Crystal structure of an anti-CRISPR protein, AcrIIA1.
Nucleic acids research - 9 Jan 2018
Ka Donghyun, An So Young, Suh Jeong-Yong, Bae Euiyoung
Abstract excerpt
Clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins provide bacteria with RNA-based adaptive immunity against phage infection. To counteract this defense mechanism, phages evolved anti-CRISPR (Acr) proteins that inactivate the CRISPR-Cas systems. AcrIIA1, encoded by Listeria monocytogenes prophages, is the most prevalent among the Acr proteins targeting type...
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