Article
Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense.
Structure (London, England : 1993) - 10 Jun 2009
Wiedenheft Blake, Zhou Kaihong, Jinek Martin, Coyle Scott M, Ma Wendy, Doudna Jennifer A
Abstract excerpt
Acquired immunity in prokaryotes is achieved by integrating short fragments of foreign nucleic acids into clustered regularly interspaced short palindromic repeats (CRISPRs). This nucleic acid-based immune system is mediated by a variable cassette of up to 45 protein families that represent distinct immune system subtypes. CRISPR-associated gene 1 (cas1) encodes the only universally conserved protein component of...
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